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Cytokine. 2017 Aug;96:144-151. doi: 10.1016/j.cyto.2017.03.009. Epub 2017 Apr 11.

High level of IL-10 expression in the blood of animal models possibly relates to resistance against leptospirosis.

Author information

1
Institut Pasteur International Network, Institut Pasteur de Nouvelle-Calédonie, Group Immunity and Inflammation, Noumea, New Caledonia. Electronic address: mmatsui@pasteur.nc.
2
Institut Pasteur International Network, Institut Pasteur de Nouvelle-Calédonie, Leptospirosis Research and Expertise Unit, Noumea, New Caledonia.
3
Center for Translational Research, Technology Core, Institut Pasteur, Paris, France.
4
Anatomic Pathology Laboratory, Gaston-Bourret Territorial Hospital Center, Noumea, New Caledonia.

Abstract

Leptospirosis is a severe zoonosis which immunopathogenesis is poorly understood. We evaluated correlation between acute form of the disease and the ratio of the anti-inflammatory cytokine IL-10 to the pro-inflammatory TNF-α and IL-1β expression during the early phase of infection comparing resistant mice and susceptible hamsters infected with two different species of virulent Leptospira. The IL-10/TNF-α and IL-10/IL-1β expression ratios were higher in mouse compared to hamster independently of the Leptospira strain, suggesting a preponderant role of the host response and notably these cytokines in the clinical expression and survival to leptospirosis. Using an IL-10 neutralization strategy in Leptospira-infected mouse model, we also showed evidence of a possible role of this cytokine on host susceptibility, bacterial clearance and on regulation of cytokine gene expression.

KEYWORDS:

Cytokine; IL-10; IL-1β; In vivo; Leptospirosis; TNF-α

PMID:
28410507
DOI:
10.1016/j.cyto.2017.03.009
[Indexed for MEDLINE]
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