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PLoS One. 2017 Apr 14;12(4):e0175536. doi: 10.1371/journal.pone.0175536. eCollection 2017.

Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty - Phthalate contaminated-foodstuff episode in Taiwan.

Author information

1
National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
2
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
3
Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.
4
Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
5
Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
6
Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang Ming University, Taipei, Taiwan.
7
Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan.
8
Department of gynecology and obstetrics, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.
9
Division of Health Policy Translation, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
10
Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.

Abstract

BACKGROUND:

In May 2011, a major incident involving phthalates-contaminated foodstuffs occurred in Taiwan. Di-(2-ethylhexyl) phthalate (DEHP) was added to foodstuffs, mainly juice, jelly, tea, sports drink, and dietary supplements. Concerns arose that normal pubertal development, especially reproductive hormone regulation in children, could be disrupted by DEHP exposure.

OBJECTIVE:

To investigate the association between phthalate exposure and reproductive hormone levels among children following potential exposure to phthalate-tainted foodstuffs.

METHODS:

A total of 239 children aged <12 years old were recruited from 3 hospitals in north, central, and south Taiwan after the episode. Structured questionnaires were used to collect the frequency and quantity of exposures to 5 categories of phthalate-contaminated foodstuffs to assess phthalate exposure in children. Urine samples were collected for the measurement of phthalate metabolites. The estimated daily intake of DEHP exposure at the time of the contamination incident occurred was calculated using both questionnaire data and urinary DEHP metabolite concentrations. Multiple regression analyses were applied to assess associations between phthalate exposure and reproductive hormone levels in children.

RESULTS:

After excluding children with missing data regarding exposure levels and hormone concentrations and girls with menstruation, 222 children were included in the statistical analyses. After adjustment for age and birth weight, girls with above median levels of urinary mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and sum of mono-(2-ethylhexyl) phthalate concentrations had higher odds of above median follicle-stimulating hormone concentrations. Girls with above median estimated average daily DEHP exposures following the contamination episode also had higher odds of sex hormone-binding globulin above median levels.

CONCLUSIONS:

Phthalate exposure was associated with alterations of reproductive hormone levels in girls.

PMID:
28410414
PMCID:
PMC5391940
DOI:
10.1371/journal.pone.0175536
[Indexed for MEDLINE]
Free PMC Article

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