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Adipocyte. 2017 Oct 2;6(4):304-313. doi: 10.1080/21623945.2017.1313374. Epub 2017 Apr 14.

Meeting report of the 2016 bone marrow adiposity meeting.

Author information

1
a Erasmus MC, Department of Internal Medicine , Laboratory for Calcium and Bone Metabolism , Rotterdam , the Netherlands.
2
b Mayo Clinic, Department of Orthopedic Surgery and Biochemistry & Molecular Biology , Rochester , MN , USA.

Abstract

There is considerable interest in the physiology and pathology, as well as the cellular and molecular biology, of bone marrow adipose tissue (BMAT). Because bone marrow adiposity is linked not only to systemic energy metabolism, but also to both bone marrow and musculoskeletal disorders, this biologic compartment has become of major interest to investigators from diverse disciplines. Bone marrow adiposity represents a virtual multi-tissue endocrine organ, which encompasses cells from multiple developmental lineages (e.g., mesenchymal, myeloid, lymphoid) and occupies all the non-osseous and non-cartilaginous space within long bones. A number of research groups are now focusing on bone marrow adiposity to understand a range of clinical afflictions associated with bone marrow disorders and to consider mechanisms-based strategies for future therapies.

KEYWORDS:

adipocyte; adiposity; bone marrow; bone marrow adipose tissue; fat

PMID:
28410005
PMCID:
PMC5736244
DOI:
10.1080/21623945.2017.1313374
[Indexed for MEDLINE]
Free PMC Article

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