Format

Send to

Choose Destination
J Med Case Rep. 2017 Apr 14;11(1):105. doi: 10.1186/s13256-017-1259-6.

Treatment of post-anesthesia dementia with perispinal etanercept injection and hyperbaric oxygen therapy: a case report.

Author information

1
The Neuroscience Center, 440 Lake Cook Road, Suite 2, Deerfield, IL, 60015, USA. srdbest@neuroscience.md.
2
PathFinder Brain SPECT, 440 Lake Cook Road, Suite 3, Deerfield, IL, 60015, USA.

Abstract

BACKGROUND:

We report on the first case of successful treatment for post-anesthesia dementia with perispinal etanercept injection combined with hyperbaric oxygen therapy.

CASE PRESENTATION:

Our patient was a 77-year-old Caucasian man of Mexican ethnicity who presented to our clinic 4.5 years after a knee replacement surgery. Immediately post-surgery, the patient began to show dramatic cognitive, physical, and emotional impairment compared with his presurgical state; these symptoms were still present when he arrived at our clinic. A clinical assessment and brain single-photon emission computer tomography were performed. Diagnoses of dementia with major cognitive deficits and aphasia were established. A 40-session course of hyperbaric oxygen therapy was initiated to address our patient's impairments. After the first ten hyperbaric oxygen therapy treatments, our patient was administered 25 mg perispinal etanercept injections approximately once weekly for 5 months. Starting after the first perispinal etanercept injection, our patient began showing progressive improvements. By the 5-month follow-up, his cognitive and physical function were substantially restored. A follow-up single-photon emission computer tomography scan showed increased perfusion in several small, localized areas.

CONCLUSIONS:

In this case of dementia and major cognitive disorder post major surgery and anesthesia, the very beneficial effect of combining hyperbaric oxygen therapy with perispinal etanercept is outlined.

KEYWORDS:

Case report; Dementia; HBOT; Perispinal etanercept; SPECT

PMID:
28407792
PMCID:
PMC5391550
DOI:
10.1186/s13256-017-1259-6
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center