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Diabetes Res Clin Pract. 2017 May;127:254-264. doi: 10.1016/j.diabres.2017.03.020. Epub 2017 Mar 24.

Plasma adiponectin levels, ADIPOQ variants, and incidence of type 2 diabetes: A nested case-control study.

Author information

1
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan; Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: atgoto@ncc.go.jp.
2
Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan; Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan.
3
Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
4
Department of Metabolic Disorder, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
5
Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan.
6
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
7
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan; Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Abstract

AIMS:

To clarify the associations between plasma adiponectin levels and ADIPOQ variants with type 2 diabetes incidence in a general Japanese population.

METHODS:

We conducted a case-control study nested within the Japan Public Health Center-based Prospective Study. We measured plasma adiponectin levels and genotyped +45T>G (rs2241766) and +276G>T (rs1501299) in the ADIPOQ gene among 417 incident diabetes cases and 1197 control subjects matched by age, sex, and area.

RESULTS:

After potential confounding factor adjustment, the multivariable-adjusted diabetes odds ratios (ORs) were 0.59 (95% confidence interval [CI]: 0.51-0.68) and 0.68 (95% CI: 0.60-0.78) per 1 standard deviation increment in the log-transformed levels of total- and high-molecular-weight (HMW) adiponectin levels, respectively. However, the ADIPOQ variants were not significantly associated with plasma adiponectin levels (for total adiponectin, +45 P=0.15 and +276 P=0.08) and diabetes risk (+45 P=0.70 and +276 P=0.72) under the additive genetic model.

CONCLUSIONS:

Our prospective findings suggest that both total and HMW adiponectin levels are strongly and inversely associated with diabetes risk after adjustment for potential confounding factors; however, the ADIPOQ variants +45 and +276 are not associated with adiponectin levels and diabetes risk in the general Japanese population.

KEYWORDS:

ADIPOQ; Adiponectin; Type 2 diabetes

PMID:
28407551
DOI:
10.1016/j.diabres.2017.03.020
[Indexed for MEDLINE]
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