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Eur J Obstet Gynecol Reprod Biol. 2017 Jun;213:17-21. doi: 10.1016/j.ejogrb.2017.04.003. Epub 2017 Apr 2.

Impact of large ovarian endometriomas on the response to superovulation for in vitro fertilization: A retrospective study.

Author information

1
Academic Unit of Obstetrics and Gynecology, IRCCS AOU San Martino - IST, Largo R. Benzi 10, 16132 Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy; Piazza della Vittoria 14, S.r.l., Italy.
2
Academic Unit of Obstetrics and Gynecology, IRCCS AOU San Martino - IST, Largo R. Benzi 10, 16132 Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy.
3
Academic Unit of Obstetrics and Gynecology, IRCCS AOU San Martino - IST, Largo R. Benzi 10, 16132 Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy; Piazza della Vittoria 14, S.r.l., Italy. Electronic address: simone.ferrero@unige.it.

Abstract

OBJECTIVE:

To assess the response to superovulation for in vitro fertilization (IVF) in patients with unilateral endometriomas with diameter ≥5cm and in the contralateral healthy ovary.

STUDY DESIGN:

This retrospective analysis of a prospectively collected database included patients who underwent superovulation for IVF/ICSI cycles and had unoperated single unilateral endometrioma with diameter ≥5cm and healthy contralateral ovary. The primary outcome of the study was to compare the number of oocyte retrieved in the ovary with the endometrioma and the contralateral healthy ovary.

RESULTS:

The total number of follicles was lower in ovaries with endometriomas (2.6±1.3) than in healthy ovaries (4.8±2.0; p<0.001). The number of codominant follicles and the total number of oocytes retrieved were lower in ovaries with endometriomas (1.5±0.9 and 2.0±1.2) than in the contralateral ovaries (3.7±1.5 and 4.2±1.7; p<0.001, respectively). The number of oocytes retrieved suitable for fertilization was lower in ovaries with endometriomas (1.5±1.1) than in the healthy ovaries (3.3±1.5; p<0.001). The total number of oocytes retrieved and the number of oocytes retrieved suitable for fertilization were lower in ovaries with endometriomas respectively in 21 (80.8%) and in 20 (76.9%) cases. The decreased responsiveness to ovarian superovulation was confirmed considering women with ultrasonographic diagnosis of deep infiltrating endometriosis. 30.8% of patients had positive HCG; the pregnancy rate was 23.1%.

CONCLUSION:

The presence of large endometriomas (≥5cm) at time of IVF significantly decreases the number of oocyte retrieved compared with the contralateral healthy ovaries.

KEYWORDS:

Endometriomas; ICSI; Oocyte; Pregnancy; in vitro fertilization

PMID:
28407512
DOI:
10.1016/j.ejogrb.2017.04.003
[Indexed for MEDLINE]

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