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Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102. doi: 10.1093/nar/gkx247.

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.

Tang Z1, Li C1,2, Kang B1, Gao G3, Li C2,3, Zhang Z1,2,4,5.

Author information

1
BIOPIC, School of Life Sciences, Peking University, Beijing 100871, China.
2
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
3
School of Life Sciences, Peking University, Beijing 100871, China.
4
Department of Biomolecular Engineering, University of California, Santa Cruz, CA 95064, USA.
5
Beijing Advanced Innovation Center for Genomics, Peking University, Beijing 100871, China.

Abstract

Tremendous amount of RNA sequencing data have been produced by large consortium projects such as TCGA and GTEx, creating new opportunities for data mining and deeper understanding of gene functions. While certain existing web servers are valuable and widely used, many expression analysis functions needed by experimental biologists are still not adequately addressed by these tools. We introduce GEPIA (Gene Expression Profiling Interactive Analysis), a web-based tool to deliver fast and customizable functionalities based on TCGA and GTEx data. GEPIA provides key interactive and customizable functions including differential expression analysis, profiling plotting, correlation analysis, patient survival analysis, similar gene detection and dimensionality reduction analysis. The comprehensive expression analyses with simple clicking through GEPIA greatly facilitate data mining in wide research areas, scientific discussion and the therapeutic discovery process. GEPIA fills in the gap between cancer genomics big data and the delivery of integrated information to end users, thus helping unleash the value of the current data resources. GEPIA is available at http://gepia.cancer-pku.cn/.

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