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Nutrients. 2017 Apr 13;9(4). pii: E379. doi: 10.3390/nu9040379.

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study.

Granic A1,2,3, Hill TR4,5, Davies K6,7,8, Jagger C9,10, Adamson A11,12,13, Siervo M14,15,16, Kirkwood TB17,18, Mathers JC19,20,21, Sayer AA22,23,24.

Author information

1
Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. antoneta.granic@newcastle.ac.uk.
2
NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. antoneta.granic@newcastle.ac.uk.
3
Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. antoneta.granic@newcastle.ac.uk.
4
Human Nutrition Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. tom.hill@newcastle.ac.uk.
5
School of Agriculture, Food and Rural Development, Kings Road, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. tom.hill@newcastle.ac.uk.
6
Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. karen.davies@newcastle.ac.uk.
7
NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. karen.davies@newcastle.ac.uk.
8
Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. karen.davies@newcastle.ac.uk.
9
Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. carol.jagger@newcastle.ac.uk.
10
Institute for Health and Society, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK. carol.jagger@newcastle.ac.uk.
11
Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. ashley.adamson@newcastle.ac.uk.
12
Human Nutrition Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. ashley.adamson@newcastle.ac.uk.
13
Institute for Health and Society, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK. ashley.adamson@newcastle.ac.uk.
14
Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. mario.siervo@newcastle.ac.uk.
15
Human Nutrition Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. mario.siervo@newcastle.ac.uk.
16
Institute of Cellular Medicine, Newcastle University, William Leech Building, Newcastle upon Tyne NE2 4HH, UK. mario.siervo@newcastle.ac.uk.
17
Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. tom.kirkwood@newcastle.ac.uk.
18
Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. tom.kirkwood@newcastle.ac.uk.
19
Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. john.mathers@newcastle.ac.uk.
20
Human Nutrition Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. john.mathers@newcastle.ac.uk.
21
Institute of Cellular Medicine, Newcastle University, William Leech Building, Newcastle upon Tyne NE2 4HH, UK. john.mathers@newcastle.ac.uk.
22
Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. avan.sayer@newcastle.ac.uk.
23
NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. avan.sayer@newcastle.ac.uk.
24
Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. avan.sayer@newcastle.ac.uk.

Abstract

Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study (n = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1-SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = -2.56 (0.96); SQ4: -2.16 (1.06)) and women (SQ1: -1.10 (0.52); SQ4: -1.28 (0.50)) (all p ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (-0.40 (0.1)), (both p ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men.

KEYWORDS:

25(OH)D; Timed Up-and-Go Test; grip strength; muscle strength; physical performance; very old adults

PMID:
28406464
PMCID:
PMC5409718
DOI:
10.3390/nu9040379
[Indexed for MEDLINE]
Free PMC Article

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