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J Sex Marital Ther. 2018 Jan 2;44(1):61-72. doi: 10.1080/0092623X.2017.1318797. Epub 2017 May 12.

Lack of Increase in Sexual Drive and Function After Dopaminergic Stimulation in Women.

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a Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology and Sexual Medicine , Hannover Medical School , Hannover , Germany.
b NICA-NeuroImaging and Clinical Applications , Hannover Medical School , Hannover , Germany.
c Clinic for Reproductive Endocrinology , University Hospital , Zürich , Switzerland.


Human and animal data indicate that the dopaminergic system plays a crucial role in sexual drive and function. Using a double-blind, placebo-controlled crossover design, this prototype study investigated the effect of the D2 dopamine agonist cabergoline on sexual parameters in 13 healthy women. Cardiovascular and genital parameters were monitored continuously. Sexual drive and function were measured using self-report sexual experience scales. In contrast to previous theories and assumptions, we found that cabergoline did not alter objective and subjective sexual parameters in healthy women. This finding suggests that there may be sex differences in the influence of the dopaminergic system on human sexual functioning.

[Indexed for MEDLINE]

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