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Eur J Nutr. 2017 Apr 12. doi: 10.1007/s00394-017-1449-4. [Epub ahead of print]

Higher dietary acid load is associated with a higher prevalence of frailty, particularly slowness/weakness and low physical activity, in elderly Japanese women.

Author information

1
Department of Nutrition, School of Human Cultures, University of Shiga Prefecture, Shiga, Japan.
2
Interfaculty Initiative in Information Studies, University of Tokyo, Tokyo, 113 0033, Japan. kenmrkm@m.u-tokyo.ac.jp.
3
Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Tokyo, Japan.
4
Department of Social and Preventive Epidemiology, Graduated School of Medicine, University of Tokyo, Tokyo, Japan.

Abstract

OBJECTIVE:

Epidemiologic evidence on the potential effects of dietary acid load on frailty is lacking. This cross-sectional study examined the association between dietary acid load and frailty.

METHODS:

This study was based on self-reported data obtained from 2176 Japanese women aged 65-94 years. Dietary acid load was characterized as potential renal acid load (PRAL) and net endogenous acid production (NEAP), based on information on nutrient intake, obtained from a validated brief diet history questionnaire. Frailty score (0-5) was defined as the sum of slowness/weakness (two points), exhaustion (one point), low physical activity (one point), and unintentional weight loss (one point). A score of ≥3 was classified as indicating frailty.

RESULTS:

The prevalence of frailty was 17.9%. After adjustment for potential confounding factors, higher PRAL and NEAP were associated with a higher prevalence of frailty. Adjusted OR (95% CI) for frailty in the highest compared to the lowest quintiles was 1.59 (1.08, 2.34) for PRAL (P for trend = 0.048) and 1.42 (0.98, 2.06) for NEAP (P for trend = 0.03). PRAL and NEAP also showed positive associations with the prevalence of slowness/weakness and low physical activity (all P for trend ≤0.03). PRAL (but not NEAP) was positively associated with the prevalence of exhaustion (P for trend = 0.04). There was no association for unintentional weight loss.

CONCLUSIONS:

Dietary acid load was positively associated with the prevalence of frailty, particularly slowness/weakness and low physical activity, in elderly Japanese women.

KEYWORDS:

Elderly Japanese women; Epidemiology; Frailty; Net endogenous acid production; Potential renal acid load

PMID:
28405820
DOI:
10.1007/s00394-017-1449-4
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