Format

Send to

Choose Destination
Oncotarget. 2017 Jul 11;8(28):45143-45153. doi: 10.18632/oncotarget.16658.

Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis.

Author information

1
Department of Endocrinology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
2
Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's Hospital, Guiyang 550000, China.
3
Information Resources, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
4
Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
5
Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China.

Abstract

Previous epidemiological research suggests polymorphisms in long non-coding RNA (lncRNA) H19 are associated with an increased risk of cancer, but the results are inconsistent. We therefore conducted a meta-analysis to more accurately determine the association between lncRNA H19 polymorphisms and cancer risk. The PubMed, Embase, and Science Citation Index online databases were searched and 11 relevant studies involving a total of 33,209 participants were identified. Odds ratios (ORs) and corresponding 95% confidence interval (CIs) from these studies were used to detect associations between H19 polymorphisms and cancer risk using five genetic models. The pooled result suggested that the rs2839698 G>A polymorphism was associated with digestive cancer risk in all five models. Moreover, a protective effect against cancer development was observed for the T allele variant of the rs2107425 C>T polymorphism, especially in Caucasian patient populations. No significant associations were found between lncRNA H19 rs217727 G>A polymorphism and cancer risk. In summary, the rs2839698 G>A and rs2107425 C>T polymorphisms in lncRNA H19 may therefore play opposing roles during cancer development, and their effects may vary depending on cancer type and patient ethnicity.

KEYWORDS:

H19; cancer; meta-analysis; polymorphism

PMID:
28404885
PMCID:
PMC5542173
DOI:
10.18632/oncotarget.16658
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Impact Journals, LLC Icon for PubMed Central
Loading ...
Support Center