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Physiology (Bethesda). 2017 May;32(3):246-260. doi: 10.1152/physiol.00041.2016.

In Vitro Models to Study Human Lung Development, Disease and Homeostasis.

Miller AJ1,2, Spence JR3,1,1,4.

Author information

1
PhD Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan.
2
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
3
PhD Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan; spencejr@umich.edu.
4
Center for Organogenesis, University of Michigan Medical School, Ann Arbor, Michigan.

Abstract

The main function of the lung is to support gas exchange, and defects in lung development or diseases affecting the structure and function of the lung can have fatal consequences. Most of what we currently understand about human lung development and disease has come from animal models. However, animal models are not always fully able to recapitulate human lung development and disease, highlighting an area where in vitro models of the human lung can compliment animal models to further understanding of critical developmental and pathological mechanisms. This review will discuss current advances in generating in vitro human lung models using primary human tissue, cell lines, and human pluripotent stem cell derived lung tissue, and will discuss crucial next steps in the field.

PMID:
28404740
PMCID:
PMC6148341
DOI:
10.1152/physiol.00041.2016
[Indexed for MEDLINE]
Free PMC Article

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