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Soc Cogn Affect Neurosci. 2017 Jun 1;12(6):993-1000. doi: 10.1093/scan/nsx027.

Positive affect predicts cerebral glucose metabolism in late middle-aged adults.

Author information

1
Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, Madison, WI, USA.
2
Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
3
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
4
Department of Biostatistics & Research, School of Nursing, George Washington University, Washington, DC, USA.
5
Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Abstract

Positive affect is associated with a number of health benefits; however, few studies have examined the relationship between positive affect and cerebral glucose metabolism, a key energy source for neuronal function and a possible index of brain health. We sought to determine if positive affect was associated with cerebral glucose metabolism in late middle-aged adults (nā€‰=ā€‰133). Participants completed the positive affect subscale of the Center for Epidemiological Studies Depression Scale at two time points over a two-year period and underwent 18F-fluorodeoxyglucose-positron emission tomography scanning. After controlling for age, sex, perceived health status, depressive symptoms, anti-depressant use, family history of Alzheimer's disease, APOE Īµ4 status and interval between visits, positive affect was associated with greater cerebral glucose metabolism across para-/limbic, frontal, temporal and parietal regions. Our findings provide evidence that positive affect in late midlife is associated with greater brain health in regions involved in affective processing and also known to be susceptible to early neuropathological processes. The current findings may have implications for interventions aimed at increasing positive affect to attenuate early neuropathological changes in at-risk individuals.

KEYWORDS:

FDG-PET; cerebral glucose metabolism; health; neuroimaging; positive affect; well-being

PMID:
28402542
PMCID:
PMC5472120
DOI:
10.1093/scan/nsx027
[Indexed for MEDLINE]
Free PMC Article

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