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Birth Defects Res. 2017 Jul 3;109(11):809-815. doi: 10.1002/bdr2.1023. Epub 2017 Apr 12.

Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment.

Author information

1
Department of Rheumatology, University of California San Diego, San Diego, California.
2
Department of Pediatric and Adolescent Dermatology, University of California San Diego, San Diego, California.
3
Department of Pediatrics, University of California San Diego, San Diego, California.
4
Department of Family Medicine and Public Health, University of California San Diego, San Diego, California.

Abstract

Infantile hemangiomas (IHs) are the most common vascular tumors in infants, appearing in early infancy and ultimately regressing with time. Clinical presentation may vary, with a minority of lesions causing impairment of vital function (e.g., respiratory or visual obstruction), permanent scarring, and/or disfigurement. The pathogenesis of IH is complex and poorly understood. Risk factors implicated in their development include preterm birth and placental anomalies. IH presents a myriad of clinical challenges, including correct diagnosis and whether or not to pursue treatment. This article is a review of the current literature regarding pathogenesis, clinical presentation, treatment, and prognosis of IH. Birth Defects Research 109:809-815, 2017.

KEYWORDS:

beta blockade; glucose transporter-1 (GLUT-1); hemangioma; hypoxia; pregnancy; vascular endothelial growth factor (VEGF)

PMID:
28402073
PMCID:
PMC5839165
DOI:
10.1002/bdr2.1023
[Indexed for MEDLINE]
Free PMC Article

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