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Acta Obstet Gynecol Scand. 2017 Aug;96(8):991-997. doi: 10.1111/aogs.13150. Epub 2017 May 16.

Women's attitude towards routine human platelet antigen-screening in pregnancy.

Author information

1
Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.
2
Department Immunohematology Diagnostics, Sanquin, Amsterdam, The Netherlands.
3
Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands.
4
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

INTRODUCTION:

Fetal and neonatal alloimmune thrombocytopenia is a potentially life-threatening disease with excellent preventative treatment available for subsequent pregnancies. To prevent index cases, the effectiveness of a population-based screening program has been suggested repeatedly. Therefore, we aimed to evaluate women's attitude towards possible future human platelet antigen-screening in pregnancy.

MATERIAL AND METHODS:

We performed a cross-sectional questionnaire study among healthy pregnant women receiving prenatal care in one of seven participating midwifery practices. Attitude was assessed using a questionnaire based on the validated Multidimensional Measurement of Informed Choice model, containing questions assessing knowledge, attitude and intention to participate.

RESULTS:

A total of 143 of the 220 women (65%) completed and returned the questionnaire. A positive attitude towards human platelet antigen-screening was expressed by 91% of participants, of which 94% was based on sufficient knowledge. Attitude was more likely to be negatively influenced by the opinion that screening can be frightening. Informed choices were made in 87% and occurred significantly less in women from non-European origin, 89% in European women vs. 60% in non-European women (p = 0.03).

CONCLUSIONS:

Pregnant women in the Netherlands expressed a positive attitude towards human platelet antigen-screening in pregnancy. We therefore expect a high rate of informed uptake when human platelet antigen-screening is implemented. In future counseling on human platelet antigen-screening, ethnicity and possible anxiety associated with a screening test need to be specifically addressed.

KEYWORDS:

Screening; attitude; fetal and neonatal alloimmune thrombocytopenia; human platelet antigen; informed choice; questionnaire

PMID:
28401538
DOI:
10.1111/aogs.13150
[Indexed for MEDLINE]

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