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Cell Tissue Res. 2017 Jul;369(1):119-126. doi: 10.1007/s00441-017-2606-z. Epub 2017 Apr 12.

Using Drosophila nephrocytes in genetic kidney disease.

Author information

1
Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
2
Imagine Institute, Paris Descartes University-Sorbonne Paris Cité, 75015, Paris, France. matias.simons@institutimagine.org.
3
Institut Imagine, 24 Boulevard du Montparnasse, Paris, France. matias.simons@institutimagine.org.

Abstract

Renal diseases are a growing health burden, and innovative models to study their pathomechanisms are greatly needed. Here, we highlight how the fruit fly Drosophila melanogaster can be used to model kidney diseases. We focus on the nephrocyte that has recently been shown to exhibit podocyte and proximal tubular cell features. These cells can be manipulated with precise genetic tools to dissect filtration and reabsorption mechanisms. Thus, they represent a novel and easy-to-use alternative in experimental nephrology.

KEYWORDS:

Drosophila; Kidney; Podocytes; Proximal tubules; Renal genetics

PMID:
28401308
DOI:
10.1007/s00441-017-2606-z
[Indexed for MEDLINE]

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