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Cell Mol Life Sci. 2017 Aug;74(16):2999-3009. doi: 10.1007/s00018-017-2511-3. Epub 2017 Apr 11.

Vinculin in cell-cell and cell-matrix adhesions.

Author information

1
Department of Biochemistry, University of Iowa, Iowa City, IA, 52242, USA.
2
Department of Biochemistry, University of Iowa, Iowa City, IA, 52242, USA. kris-demali@uiowa.edu.

Abstract

Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. We also highlight the recent understanding of how vinculin responds to and transmits force at integrin- and cadherin-containing adhesion complexes to the cytoskeleton. Furthermore, we discuss roles of vinculin in binding to and rearranging the actin cytoskeleton.

KEYWORDS:

Cadherins; Cell adhesion; Cell migration; Force and mechanotransduction; Integrins; Vinculin

PMID:
28401269
PMCID:
PMC5501900
DOI:
10.1007/s00018-017-2511-3
[Indexed for MEDLINE]
Free PMC Article

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