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J Cell Biol. 2017 May 1;216(5):1227-1229. doi: 10.1083/jcb.201703020. Epub 2017 Apr 11.

Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis.

Author information

1
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada molday@mail.ubc.ca goldberg@oakland.edu.
2
Eye Research Institute, Oakland University, Rochester, MI 48309 molday@mail.ubc.ca goldberg@oakland.edu.

Abstract

Formation of membrane discs in photoreceptor cells requires evagination of its ciliary plasma membrane by an unknown molecular mechanism. Salinas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608081) show that peripherin (also known as peripherin-2 or peripherin-2/rds) diverts membrane traffic to photoreceptor disc formation by inhibiting ectosome release from the cilium.

PMID:
28400442
PMCID:
PMC5412577
DOI:
10.1083/jcb.201703020
[Indexed for MEDLINE]
Free PMC Article

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