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Mol Cell Endocrinol. 2017 Sep 15;453:36-45. doi: 10.1016/j.mce.2017.04.008. Epub 2017 Apr 9.

The role of vitamin D in the endocrinology controlling calcium homeostasis.

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Department of Nutrition Science, Room G1B Stone Hall, Purdue University, West Lafayette, IN 47907-2059, United States. Electronic address:


Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium levels so that they are maintained within a very narrow range. To achieve this goal, regulatory events occur in coordination at multiple tissues, e.g. the intestine, kidney, bone, and parathyroid gland. Production of the vitamin D endocrine hormone, 1,25 dihydroxyvitamin D (1,25(OH)2 D) is regulated by habitual dietary calcium intake and physiologic states like growth, aging, and the menopause. The molecular actions of 1,25(OH)2 D on calcium regulating target tissues are mediated predominantly by transcription controlled by the vitamin D receptor. A primary role for 1,25(OH)2 D during growth is to increase intestinal calcium absorption so that sufficient calcium is available for bone mineralization. However, vitamin D also has specific actions on kidney and bone.


Absorption; Endocrinology; Excretion; Homeostasis; Parathyroid hormone

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