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Curr Opin Chem Biol. 2017 Jun;38:87-96. doi: 10.1016/j.cbpa.2017.03.014. Epub 2017 Apr 8.

Host defense antimicrobial peptides as antibiotics: design and application strategies.

Author information

1
Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, USA.
2
Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, USA; Department of Physics, JNTUA College of Engineering, Anantapur 515002, India.
3
Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, USA. Electronic address: gwang@unmc.edu.

Abstract

This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino acids, vitamin D and sunlight), the use of engineered probiotic bacteria to deliver peptides, the design of prodrug and peptide conjugates to improve specific targeting. In addition, combined uses of newly developed AMPs with existing antimicrobial agents may provide a practical avenue for effective management of antibiotic-resistant bacteria (superbugs), including biofilms. Finally, we highlight AMPs already in use or under clinical trials.

PMID:
28399505
PMCID:
PMC5494204
DOI:
10.1016/j.cbpa.2017.03.014
[Indexed for MEDLINE]
Free PMC Article

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