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Curr Opin Neurobiol. 2017 Jun;44:72-79. doi: 10.1016/j.conb.2017.03.016. Epub 2017 Apr 8.

Sleep, synaptic homeostasis and neuronal firing rates.

Author information

1
Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA. Electronic address: ccirelli@wisc.edu.

Abstract

The synaptic homeostasis hypothesis (SHY) states that wake brings about a net overall increase in synaptic strength in many brain circuits that needs to be renormalized by sleep. I will review recent studies that were either specifically designed to test SHY or were interpreted accordingly, including several experiments that focused on changes in neuronal firing rates. I will emphasize that central to SHY is the idea that what is being regulated across the sleep/wake cycle is synaptic strength, not firing rate, and firing rate taken in isolation is not necessarily an adequate proxy for synaptic strength.

PMID:
28399462
PMCID:
PMC5605801
DOI:
10.1016/j.conb.2017.03.016
[Indexed for MEDLINE]
Free PMC Article

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