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Virology. 2017 Jul;507:53-63. doi: 10.1016/j.virol.2017.03.008. Epub 2017 Apr 8.

Genotypic and epitope characteristics of group A porcine rotavirus strains circulating in Canada.

Author information

1
Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, Pakistan.
2
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States.
3
Vaccines Clinical Research and Development, GlaxoSmithKline Vaccines, Cambridge, MA, United States.
4
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States. Electronic address: marth027@umn.edu.

Abstract

Surveillance of Rotavirus A (RVA) infections in North America swine populations are limited and not performed over a significant time period to properly assess the diversity of RVA strains in swine. The VP7 (G) and VP4 (P) genes of 32 Canadian RVA strains, circulating between 2009 and 2015 were sequenced, identifying the G3P[13], G5P[7], G9P[7], G9[13], and G9[19] genotype combinations. The Canadian RVA strains were compared to the RVA strains present in the swine ProSystems RCE rotavirus vaccine. The comparison revealed multiple amino acid differences in the G and P antigenic epitopes, regardless of the G and P genotypes but specifically in the Canadian G3, P[13] and P[19] genotypes. Our study further contributes to the characterization of RVA's evolution and disease mitigation among swine, which may optimize target vaccine design, thereby minimizing RVA disease in this economically important animal population.

KEYWORDS:

Antigenic epitopes; Phylogenetic; Rotavirus A virus; Vaccine

PMID:
28399437
DOI:
10.1016/j.virol.2017.03.008
[Indexed for MEDLINE]
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