Format

Send to

Choose Destination
Cancer Cell. 2017 Apr 10;31(4):469-471. doi: 10.1016/j.ccell.2017.03.009.

A CD276 Antibody Guided Missile with One Warhead and Two Targets: The Tumor and Its Vasculature.

Author information

1
Biological Sciences, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada. Electronic address: kkhan@sri.utoronto.ca.
2
Biological Sciences, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.

Abstract

In this issue of Cancer Cell, Seaman et al. demonstrate that antibody drug conjugates (ADCs) against CD276 expressed by tumor cells and tumor vasculature have promising anti-tumor activity while showing little toxicity. Importantly, these agents have the potential to target both angiogenic vessels and non-angiogenic vessels co-opted by tumor cells.

PMID:
28399405
DOI:
10.1016/j.ccell.2017.03.009
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center