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AIDS Res Hum Retroviruses. 2017 Sep;33(9):905-918. doi: 10.1089/AID.2016.0303. Epub 2017 May 10.

Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts.

Author information

1
1 Graduate College of Biomedical Sciences, Western University of Health Sciences , Pomona, California.
2
2 Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences , Pomona, California.
3
3 Department of Biological Sciences, California State Polytechnic University , Pomona, California.
4
4 Riverside University Health System , Public Health, Early Intervention/HIV, Riverside, California.
5
5 Department of Medicine, Loma Linda University School of Medicine , Loma Linda, California.
6
6 Western Diabetes Institute, Western University of Health Sciences , Pomona, California.

Abstract

HIV infects and destroys CD4+ T cells leading to a compromised immune system. In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period. Baseline measurements in HIV-positive subjects show a significant decrease in levels of interleukin (IL)-12, IL-2, and interferon (IFN)-γ, along with a substantial increase in the levels of IL-6, IL-10, transforming growth factor (TGF)-β, and free radicals, compared to healthy individuals. Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts. Levels of free radicals in CD4+ T cells stabilized, while GSH levels increased in the treatment group. Those in the placebo group showed no significant difference throughout the study. In summary, supplementation with L-GSH in HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 can help restore redox homeostasis and cytokine balance, therefore aiding the immune system to control opportunistic infections.

KEYWORDS:

AIDS; HIV; cytokines; glutathione; redox homeostasis

PMID:
28398068
PMCID:
PMC5576219
DOI:
10.1089/AID.2016.0303
[Indexed for MEDLINE]
Free PMC Article

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