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Polim Med. 2016 Jul-Dec;46(2):117-127. doi: 10.17219/pim/68170.

Investigation and Optimization of the Effect of Polymers on Drug Release of Norfloxacin from Floating Tablets.

Author information

1
Shri Bhagwan College of Pharmacy, Aurangabad, India.
2
Government College of Pharmacy, Osmanpura, Aurangabad, India.

Abstract

BACKGROUND:

Norfloxacin is fluoroquinolone anti-infective used in the treatment of urinary tract infections, prostatitis, gonorrhea and genital tract infections. It has plasma half life of 3 to 4 h requiring multiple dosing in the treatment. Releaseretarding polymers can be used to modulate the drug release of norfloxacin.

OBJECTIVES:

The objective of this study was to investigate the effect of release-retarding polymers on the drug release of norfloxacin from floating tablets.

MATERIAL AND METHODS:

Norfloxacin was procured as a gift sample from Concept Pharma Ltd. Aurangabad (India) and HPMC K100M was procured as a gift sample from Colorcon Asia Pvt. Ltd., Goa (India). The tablets were prepared by direct compression method and various pharmaceutical parameters were evaluated.

RESULTS:

It was observed that all tablet formulations F1-F9 retained the drug release up to 12 h with good floating property but only Batch-F4 complies with the USP dissolution limits with a minimum floating lag time. The drug release kinetics were evaluated by the model-dependent (curve fitting) method using PCP Disso v3 software shows Batch-F4 shows to best fit with Peppas model for which R2 value was 0.9921 and the release exponent value was 0.6892.

CONCLUSIONS:

The drug release kinetics study indicates that the floating tablets release the drug by diffusion followed by erosion mechanism. Obtained in-vitro drug release data was analyzed by design expert software for drug release at first hour and at 12th h values and found that release the selected independent variables like HPMC K100M and sodium alginate concentration has a significant effect on drug release.

KEYWORDS:

drug dissolution; floating drug delivery systems; gastroretentive drug delivery systems; norfloxacin

PMID:
28397452
DOI:
10.17219/pim/68170
[Indexed for MEDLINE]
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