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J Neurodev Disord. 2017 Apr 5;9:13. doi: 10.1186/s11689-017-9194-9. eCollection 2017.

Atypical sound discrimination in children with ASD as indicated by cortical ERPs.

Author information

1
Brain Dynamics and Cognition Team, Lyon Neuroscience Research Center; CRNL, INSERM U1028, CNRS UMR5292, University of Lyon 1, Lyon, France.
2
UMR Inserm U930, Université François Rabelais de Tours, Tours, France.
3
CHRU de Tours, Service de Pédopsychiatrie, Tours, France.
#
Contributed equally

Abstract

BACKGROUND:

Individuals with autism spectrum disorder (ASD) show a relative indifference to the human voice. Accordingly, and contrarily to their typically developed peers, adults with autism do not show a preferential response to voices in the superior temporal sulcus; this lack of voice-specific response was previously linked to atypical processing of voices. In electroencephalography, a slow event-related potential (ERP) called the fronto-temporal positivity to voice (FTPV) is larger for vocal than for non-vocal sounds, resulting in a voice-sensitive response over right fronto-temporal sites. Here, we investigated the neurophysiological correlates of voice perception in children with and without ASD.

METHODS:

Sixteen children with autism and 16 age-matched typically developing children heard vocal (speech and non-speech) and non-vocal sounds while their electroencephalographic activity was recorded; overall IQ was smaller in the group of children with ASD. ERP amplitudes were compared using non-parametric statistical tests at each electrode and in successive 20-ms time windows. Within each group, differences between conditions were assessed using a non-parametric Quade test between 0 and 400 ms post-stimulus. Inter-group comparisons of ERP amplitudes were performed using non-paired Kruskal-Wallis tests between 140 and 180 ms post-stimulus.

RESULTS:

Typically developing children showed the classical voice-sensitive response over right fronto-temporal electrodes, for both speech and non-speech vocal sounds. Children with ASD did not show a preferential response to vocal sounds. Inter-group analysis showed no difference in the processing of vocal sounds, both speech and non-speech, but significant differences in the processing of non-vocal sounds over right fronto-temporal sites.

CONCLUSIONS:

Our results demonstrate a lack of voice-preferential response in children with autism spectrum disorders. In contrast to observations in adults with ASD, the lack of voice-preferential response was attributed to an atypical response to non-vocal sounds, which was overall more similar to the event-related potentials evoked by vocal sounds in both groups. This result suggests atypical maturation processes in ASD impeding the specialization of temporal regions in voice processing.

KEYWORDS:

Auditory; Autism; Development; FTPV; Speech; Voice

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