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Respir Physiol Neurobiol. 2017 Aug;242:66-72. doi: 10.1016/j.resp.2017.04.002. Epub 2017 Apr 7.

Newborn blood gas derangements of children born extremely preterm and neurocognitive dysfunctions at age 10 years.

Author information

1
Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: alan.leviton@childrens.harvard.edu.
2
Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
3
Boston University School of Medicine, Boston, MA, USA.
4
University of North Carolina School of Medicine, Chapel Hill, NC, USA.
5
Boston University School of Medicine, Boston, MA, USA; Boston Medical Center, Boston, MA, USA.

Abstract

Among 740 children born extremely preterm, we evaluated the relationship between the highest and lowest quartiles of the distributions of PaO2 and PaCO2, as well as the lowest quartile of pH on one day, and separately on two days, and the risk of neurocognitive, language, and behavioral dysfunctions at age 10 years. Children who had hypoxemia, hyperoxemia, hypocapnia, hypercapnia, and acidemia, sometimes on only one day, and sometimes on two or more days, were more likely than others to have a high illness severity score (within the first 12 postnatal hours), and 10 years later to have multiple dysfunctions. The tendency of blood gas derangements to be associated with high illness severity scores and with multiple dysfunctions 10 years later is compatible with the possibility that blood gas derangements are indicators of physiologic instability/vulnerability/immaturity rather than contributors to brain damage.

KEYWORDS:

Blood gas analysis; Brain; Development; Infant; Newborn; Premature

PMID:
28396202
PMCID:
PMC5502708
DOI:
10.1016/j.resp.2017.04.002
[Indexed for MEDLINE]
Free PMC Article

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