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Brain Res. 2017 Jun 15;1665:1-21. doi: 10.1016/j.brainres.2017.03.029. Epub 2017 Apr 7.

Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments.

Author information

1
Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.
2
Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK; Department of Anaesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
3
Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China. Electronic address: lianqingquanmz@163.com.
4
Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK. Electronic address: d.ma@imperial.ac.uk.

Abstract

Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury. This review summarizes the available information on the potential benefits of BDNF and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer's disease and Parkinson's disease. It further explores the methods in which BDNF can be applied in clinical and therapeutic settings, and the potential challenges to overcome.

KEYWORDS:

Brain injury; Brain-derived neurotrophic factor; Neuroprotection

PMID:
28396009
DOI:
10.1016/j.brainres.2017.03.029
[Indexed for MEDLINE]

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