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Gut Liver. 2017 Sep 15;11(5):635-641. doi: 10.5009/gnl16397.

Postoperative Helicobacter pylori Infection as a Prognostic Factor for Gastric Cancer Patients after Curative Resection.

Author information

1
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
2
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
3
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Background/Aims:

Few studies have evaluated the effect of Helicobacter pylori infection on the prognosis of patients diagnosed with gastric cancer (GC) after curative surgery. We investigated the association between the H. pylori infection status and clinical outcome after surgery.

Methods:

We assessed the H. pylori status of 314 patients who underwent curative resection for GC. The H. pylori status was examined using a rapid urease test 2 months after resection. Patients were followed for 10 years after surgery.

Results:

An H. pylori infection was observed in 128 of 314 patients. The median follow-up period was 93.5 months. A Kaplan-Meier analysis indicated that patients with H. pylori had a higher cumulative survival rate than those who were negative for H. pylori. Patients with stage II cancer who tested negative for H. pylori were associated with a poor outcome. In a multivariate analysis, H. pylori-negative status was a significant independent prognostic factor for poor overall survival.

Conclusions:

Having a negative H. pylori infection status seems to indicate poor prognosis for patients with GC who have undergone curative resection. Further prospective controlled studies are needed to evaluate the mechanism by which H. pylori affects GC patients after curative surgery in Korea.

KEYWORDS:

General surgery; Helicobacter pylori; Prognosis; Stomach neoplasms

PMID:
28395509
PMCID:
PMC5593325
DOI:
10.5009/gnl16397
[Indexed for MEDLINE]
Free PMC Article

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