Format

Send to

Choose Destination
Am J Clin Pathol. 2017 Feb 1;147(2):153-170. doi: 10.1093/ajcp/aqw216.

B-Cell and Classical Hodgkin Lymphomas Associated With Immunodeficiency: 2015 SH/EAHP Workshop Report-Part 2.

Author information

1
From the VU University Medical Center, Amsterdam, the Netherlands.
2
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
3
Queen Elizabeth Hospital, Kowloon, Hong Kong.
4
HMDS, St James's University Hospital, Leeds, United Kingdom.
5
Stanford University School of Medicine, Stanford, CA.
6
Weill Medical College of Cornell University, New York.
7
National Institutes of Health, Bethesda, MD.
8
University of California Los Angeles Medical Center, Los Angeles.

Abstract

Objectives:

The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology submitted small and large B-cell lymphomas (BCLs), including classical Hodgkin lymphoma (CHL), in the context of immunodeficiency.

Methods:

Clinicopathologic and molecular features were studied to explore unifying concepts in malignant B-cell proliferations across immunodeficiency settings.

Results:

Cases submitted to the workshop spanned small BCLs presenting as nodal or extranodal marginal zone lymphoma and lymphoplasmacytic lymphoma, Epstein-Barr virus (EBV) positive in 75% of cases. Submitted large BCLs formed a spectrum from diffuse large B-cell lymphoma (DLBCL) to CHL across immunodeficiency settings. Additional studies demonstrated overexpression of PD-L1 and molecular 9p24 alterations in the large BCL spectrum and across different immunodeficiency settings.

Conclusions:

Small BCLs occur in all immunodeficiency settings, and EBV positivity is essential for their recognition as immunodeficiency related. Large BCLs include a spectrum from DLBCL to CHL across all immunodeficiency settings; immunohistochemical and molecular features are suggestive of shared pathogenetic mechanisms involving PD-L1 immune checkpoints.

KEYWORDS:

9p24; Autoimmunity; Classical Hodgkin lymphoma; Iatrogenic immunodeficiency; Large B-cell lymphoma; Marginal zone lymphoma; PD-L1; Posttransplant lymphoproliferative disorder; Primary immunodeficiency; T-cell/histiocyte-rich B-cell lymphoma

PMID:
28395108
PMCID:
PMC6248547
DOI:
10.1093/ajcp/aqw216
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center