Format

Send to

Choose Destination
PLoS Negl Trop Dis. 2017 Apr 10;11(4):e0005535. doi: 10.1371/journal.pntd.0005535. eCollection 2017 Apr.

Acute Q fever in febrile patients in northwestern of Iran.

Author information

1
Research Centre for Emerging and Reemerging Infectious Diseases, National Reference Laboratory for Plague, Tularemia and Q Fever, Pasteur Institute of Iran, Akanlu, Kabudar-Ahang, Hamadan, Iran.
2
Department of Epidemiology and Biostatistics, Pasteur Institute of Iran, Tehran, Iran.
3
Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
4
Institute of Natural and Mathematical Science, Massey University, Auckland, New Zealand.
5
Department of Epidemiology and Biostatistics, School of Public Health and Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
6
Research Center of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Tabriz university of Medical Science, Tabriz, Iran.

Abstract

BACKGROUND:

Q fever is an endemic disease in different parts of Iran. This study aimed to investigate the prevalence of acute Q fever disease among at-risk individuals in northwestern Iran.

METHODOLOGY:

An etiological study was carried out in 2013 in Tabriz County. A total of 116 individuals who were in contact with livestock and had a nonspecific febrile illness were enrolled in the study. IgG phase II antibodies against Coxiella burnetii were detected using ELISA.

PRINCIPAL FINDINGS:

The prevalence of acute Q fever was 13.8% (95% confidence interval [CI]: 8.0, 21.0%). Headache (87.5%) and fatigue and weakness (81.3%) were the dominant clinical characteristics among patients whit acute Q fever. Acute lower respiratory tract infection and chills were poorly associated with acute Q fever. Furthermore, 32% (95% CI: 24, 41%) of participants had a history of previous exposure to Q fever agent (past infection). Consumption of unpasteurized dairy products was a weak risk factor for previous exposure to C. burnetii.

CONCLUSION:

This study identified patients with acute Q fever in northwestern of Iran. The evidence from this study and previous studies conducted in different regions of Iran support this fact that Q fever is one of the important endemic zoonotic diseases in Iran and needs due attention by clinical physicians and health care system.

PMID:
28394892
PMCID:
PMC5398717
DOI:
10.1371/journal.pntd.0005535
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center