Format

Send to

Choose Destination
Low Urin Tract Symptoms. 2017 May;9(2):75-81. doi: 10.1111/luts.12112. Epub 2015 Oct 9.

Treatment Patterns and Patient Reported Outcomes in Benign Prostatic Hyperplasia Patients with Overactive Bladder Symptoms.

Author information

1
Department of Urology, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
2
Department of Urology, College of Medicine, Dong-A University, Busan, Korea.
3
Department of Urology, Hanyang University Guri Hospital, Guri, Korea.
4
Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
5
Department of Urology, Hallym University College of Medicine, Chuncheon, Korea.

Abstract

OBJECTIVES:

We aimed to examine the treatment patterns, and patient-reported outcomes (PROs) in benign prostatic hyperplasia (BPH) patients with overactive bladder (OAB) symptoms.

METHODS:

Seven hundred and forty seven patients were included in this prospective observational study. The primary endpoint was to describe the medical treatment patterns for BPH patients with OAB symptoms. The secondary endpoint was to determine the PROs of these patients. Clinical outcome was assessed using International prostate symptom score (IPSS), and PROs were measured using BPH-Related QoL Questionnaire Korea 1 (BPH QoL K1) and Euroqol-5 Dimension (EQ-5D).

RESULTS:

When starting the study, 391 patients (52.3%) received α-blocker monotherapy, whereas 356 (47.7%) received combination therapy with anticholinergics. Of the 369 patients who completed the 6-month treatment, 139 patients (37.7%) still received α-blocker monotherapy, 122 (33.1%) still received combination therapy with anticholinergics, and 108 (29.3%) received subsequent anticholinergics in addition to α-blocker. When the patients were stratified, storage subscore was higher (9.5 vs. 8.8, P = 0.034) and voiding subscore (9.7 vs. 11.6, P = 0.001) was lower in patients with anticholinergics than those without it. Although all treatment groups reported a significant improvement from baseline, no significant between-group differences in changes in IPSS, EQ-5D and BPH QoL K1 was found.

CONCLUSIONS:

About one-third of patients received α-blocker monotherapy, one-third received combination therapy with anticholinergics, and another one-third received subsequent anticholinergics in addition to α-blocker. Storage subscore was higher in patients with anticholinergics than those without it, but vice-versa for voiding subscore. Similar improvement on clinical outcomes and PROs was observed in all treatment groups.

KEYWORDS:

benign prostatic hyperplasia; clinical outcomes; overactive bladder symptoms; patient-reported outcomes; treatment pattern

PMID:
28394492
DOI:
10.1111/luts.12112
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center