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Macromol Biosci. 2017 Aug;17(8). doi: 10.1002/mabi.201600540. Epub 2017 Apr 10.

Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles.

Author information

1
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
2
Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and Institute of Nano Science and Technology (INST), Hanyang University, Seoul, 04763, Republic of Korea.
3
Severance Children's Hospital, Department of Pediatrics and BK21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.

Abstract

Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis.

KEYWORDS:

differentiation; graphene oxide nanoparticle; neural stem cell; self-renewal

PMID:
28394476
DOI:
10.1002/mabi.201600540
[Indexed for MEDLINE]

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