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Histopathology. 2017 Sep;71(3):415-424. doi: 10.1111/his.13235. Epub 2017 Jun 16.

Histopathological characteristics of interstitial cystitis/bladder pain syndrome without Hunner lesion.

Author information

1
Department of Urology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Korea.
2
Department of Urology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
3
Department of Biomedical Sciences, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
4
Department of Pathology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.

Abstract

AIMS:

To assess the distinct histopathological characteristics and their clinical significance between non-Hunner-type and Hunner-type interstitial cystitis (IC)/bladder pain syndrome (BPS).

METHODS AND RESULTS:

We prospectively enrolled and classified IC/BPS patients, on the basis of cystoscopic findings, as having non-Hunner-type IC and Hunner-type IC. Specimens obtained from the posterior wall in non-Hunner-type IC cases during hydrodistension or from Hunner/non-Hunner lesions in Hunner-type IC cases during transurethral resection were evaluated. Stress urinary incontinence patients with microscopic haematuria were selected as controls. Biopsy specimens were obtained from 15 non-Hunner-type IC, 15 Hunner-type IC and 5 non-IC patients. Severe and moderate fibrosis was more frequently observed in non-Hunner-type IC than in Hunner-type IC and non-IC cases. However, severe and moderate inflammation was more frequently observed in Hunner-type IC than in non-Hunner-type IC cases. The remnant urothelium was significantly decreased in Hunner-type IC cases as compared with non-Hunner-type IC and non-IC cases (P < 0.05), and non-Hunner-type IC cases showed a higher number of mast cells than Hunner-type IC and non-IC cases (P = 0.035). Accordingly, several fibrosis-promoting genes were highly expressed in bladder tissues of non-Hunner-type IC, as compared with Hunner-type IC. Patients with severe fibrosis showed significantly higher urinary frequency and smaller bladder capacity than those with moderate and mild fibrosis (all P < 0.05).

CONCLUSIONS:

Non-Hunner-type IC is characterized by severe fibrosis and increased mast cell infiltration, whereas Hunner-type IC is characterized by severe inflammation and urothelial denudation in the entire bladder. Fibrosis in the bladder of IC/BPS patients was correlated with increased urinary frequency and decreased bladder capacity.

KEYWORDS:

fibrosis; hunner lesion; interstitial cystitis; mast cell

PMID:
28394416
DOI:
10.1111/his.13235
[Indexed for MEDLINE]

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