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J Oral Pathol Med. 2017 Nov;46(10):967-971. doi: 10.1111/jop.12579. Epub 2017 May 9.

Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours.

Author information

1
Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
2
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
3
Multidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
4
RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
5
Department of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.
6
Institut de Génétique Moléculaire, Hôpital St. Louis, Université Paris 7, Paris, France.
7
Dipartimento Universitario di Anatomia Patologica, Seconda Universita' Degli Studi di Napoli, Naples, Italy.
8
Department of Clinical Sciences/ ENT, Umeå University, Umeå, Sweden.

Abstract

BACKGROUND:

c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue.

METHODS:

Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour.

RESULTS:

All 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment.

CONCLUSIONS:

The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.

KEYWORDS:

c-MYC; radiotherapy; squamous cell carcinoma; tongue

PMID:
28393404
DOI:
10.1111/jop.12579
[Indexed for MEDLINE]

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