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ACS Omega. 2017 Mar 31;2(3):800-805. doi: 10.1021/acsomega.6b00514. Epub 2017 Mar 6.

Oxidation-Responsive, EuII/III-Based, Multimodal Contrast Agent for Magnetic Resonance and Photoacoustic Imaging.

Author information

1
Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
2
Department of Biomedical Engineering, Wayne State University , 818 W. Hancock, Detroit, Michigan 48201, United States.
3
Department of Radiology, Wayne State University , Detroit, Michigan 48201, United States.
4
Department of Radiology, Wayne State University, Detroit, Michigan 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
5
Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, Michigan 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
6
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.

Abstract

We report, for the first time, a multimodal, oxidation-responsive contrast agent for magnetic resonance imaging and photoacoustic imaging that uses the differences in the properties between Eu in the +2 and +3 oxidation states. The enhancement of contrast in T1-weighted magnetic resonance and photoacoustic imaging was observed in the +2 but not in the +3 oxidation state, and the complex is a known chemical exchange saturation transfer agent for magnetic resonance imaging in the +3 oxidation state.

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