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Iran J Otorhinolaryngol. 2017 Mar;29(91):75-81.

Otitis Media with Effusion in Children and the Impact of Risk Factors on Serum Cytokine Levels.

Author information

1
Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran.
2
ENT and Head and Neck Research Center and Department   , Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences,Tehran,Iran.
3
Department of Health, Epidemiologist, Mississippi State, United States.
4
Department of Radiology, University of Mississippi Medical Center, Mississippi State, United States.

Abstract

INTRODUCTION:

To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME).

MATERIALS AND METHODS:

We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy controls.

RESULTS:

Children with OME had significantly higher levels of IL-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0.04 pg/ml in controls (P=0.009). However, after adjusting for confounding variables, there was no significant difference in serum levels of IL-13, IL-4, IFN-γ, or TNF-α between the two groups (P=0.287, P=0.627, P=0.793, and P=0.217, respectively).

CONCLUSIONS:

The findings of this study suggest that in comparison with the control group, serum IL-5 levels were elevated in OME cases.

KEYWORDS:

Inflammatory cytokines; Interleukins; Otitis media with effusion; Pediatrics

PMID:
28393054
PMCID:
PMC5380392

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