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Kidney Res Clin Pract. 2017 Mar;36(1):39-47. doi: 10.23876/j.krcp.2017.36.1.39. Epub 2017 Mar 31.

Body mass index is inversely associated with mortality in patients with acute kidney injury undergoing continuous renal replacement therapy.

Author information

1
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; Institute of Kidney Disease Research, Yonsei University, Seoul, Korea.
2
Ewha Institute of Convergence Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
3
Division of Nephrology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea.

Abstract

BACKGROUND:

Many epidemiologic studies have reported on the controversial concept of the obesity paradox. The presence of acute kidney injury (AKI) can accelerate energy-consuming processes, particularly in patients requiring continuous renal replacement therapy (CRRT). Thus, we aimed to investigate whether obesity can provide a survival benefit in this highly catabolic condition.

METHODS:

We conducted an observational study in 212 patients who had undergone CRRT owing to various causes of AKI between 2010 and 2014. The study end point was defined as death that occurred within 30 days after the initiation of CRRT.

RESULTS:

Patients were categorized into three groups according to tertiles of body mass index (BMI). During ≥30 days after the initiation of CRRT, 39 patients (57.4%) in the highest tertile died, as compared with 58 patients (78.4%) in the lowest tertile (P = 0.02). In a multivariable analysis adjusted for cofounding factors, the highest tertile of BMI was significantly associated with a decreased risk of death (hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.37-0.87; P = 0.01). This significant association remained unaltered for 60-day (HR, 0.64; 95% CI, 0.43-0.94; P = 0.03) and 90-day mortality (HR, 0.66; 95% CI, 0.44-0.97; P = 0.03).

CONCLUSION:

This study showed that a higher BMI confer a survival benefit over a lower BMI in AKI patients undergoing CRRT.

KEYWORDS:

Acute kidney injury; Body mass index; Continuous renal replacement therapy; Mortality; Obesity

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