Abstract
In mammals, profound changes in the population and functions of adult stem cells occur with age and these changes are thought to underlie functional decline and pathophysiology at the tissue and organismal levels associated with aging. SIRT1, a member of the conserved sirtuin family, functions as an anti-aging regulator for adult stem cells. Mediated through its regulatory roles in AMPK and mTORC1 pathways as well as gene expression, SIRT1 modulate the activities of genes maintaining stem cell functions and delays cellular senescence. Further investigation of the cross-talk between SIRT1 and other longevity target genes under different physiological conditions of stem cells may help us better design intervention strategies to antagonize stem cells aging.
Keywords:
Aging; Epigenetics; Metabolism; SIRT1; Sirtuin; Stem cells.
Copyright © 2017 Elsevier B.V. All rights reserved.
MeSH terms
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Aging / genetics*
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Aging / metabolism
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Animals
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Cellular Senescence / genetics
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Epigenesis, Genetic*
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Histones / genetics
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Histones / metabolism
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Humans
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Mechanistic Target of Rapamycin Complex 1 / genetics
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Mechanistic Target of Rapamycin Complex 1 / metabolism
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Mice, Knockout
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism
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Signal Transduction*
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Sirtuin 1 / genetics*
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Sirtuin 1 / metabolism
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Stem Cells / cytology
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Stem Cells / metabolism*
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Sterol Regulatory Element Binding Protein 1 / genetics
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Sterol Regulatory Element Binding Protein 1 / metabolism
Substances
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Histones
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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Ppargc1a protein, mouse
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Srebf1 protein, mouse
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Sterol Regulatory Element Binding Protein 1
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Mechanistic Target of Rapamycin Complex 1
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Sirt1 protein, mouse
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Sirtuin 1