Format

Send to

Choose Destination
Cancer Med. 2017 May;6(5):1082-1090. doi: 10.1002/cam4.1062. Epub 2017 Apr 7.

Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging.

Author information

1
Department of Bioengineering, University of Washington, Seattle, Washington.
2
Applied Physics Laboratory, University of Washington, Seattle, Washington.
3
Department of Medicine, University of Washington, Seattle, Washington.
4
Department of Radiology, University of Washington, Seattle, Washington.

Abstract

The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques. Tumor stromal density of each tumor was measured using diffusion-weighted imaging and magnetization transfer (MT-MRI). Histologic measurement showed a similar trend with tumor fibrosis levels. Results indicated that MRI measurements can serve as a valuable tool in identifying and evaluating tumor characteristics.

KEYWORDS:

Apparent diffusion coefficient; KPC mouse model; fibrosis; magnetic resonance imaging; magnetization transfer ratio; pancreatic ductal adenocarcinoma

PMID:
28390098
PMCID:
PMC5430104
DOI:
10.1002/cam4.1062
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center