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J Biol Chem. 2017 Apr 7;292(14):6027-6028. doi: 10.1074/jbc.H117.777714. Epub 2017 Apr 7.

Exposing HIV's weaknesses.

Author information

1
From the Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, tedburyp@missouri.edu.
2
Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, and.
3
From the Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, sarafianoss@missouri.edu.
4
the Department of Biochemistry, University of Missouri, Columbia, Missouri 65212.

Abstract

The viral restriction factor SERINC5 inhibits HIV-1 infection via unknown mechanisms. Sood and co-workers now show that SERINC5 suppresses HIV-1 fusogenicity and increases sensitivity to neutralizing antibodies by perturbing the folding of the fusion machinery. This work advances our understanding of host-virus interactions and provides a compelling case for considering the host immune system in studies of restriction factor mechanisms.

PMID:
28389578
PMCID:
PMC5392592
DOI:
10.1074/jbc.H117.777714
[Indexed for MEDLINE]
Free PMC Article

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