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Toxicol Ind Health. 1988 Mar;4(1):39-47.

Influence of glibenclamide on the efficacy of calcium trisodium pentetat as an antidote for cadmium toxicity.

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1
Industrial Toxicology Research Centre, Lucknow, India.

Abstract

Cadmium causes hyperglycemia, activation of hepatic and renal gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-diphosphatase, increases hepatic and renal zinc, renal copper and decreases hepatic and renal iron levels in rats. Glibenclamide, a hypoglycemic agent, significantly reversed most of the Cd effects, enhanced fecal excretion of Cd and potentiated urinary and fecal elimination of Cd by calcium trisodium diethylenetriaminepentaacetate (CaNa3DTPA), a commonly used metal chelator. However, the restoration of Cd-induced alterations in carbohydrate metabolism was not related to elimination of Cd from the tissues.

PMID:
2838934
DOI:
10.1177/074823378800400104
[Indexed for MEDLINE]

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