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Oncogene. 1987;1(4):431-8.

An unusual alteration in c-myc in tissue from a primary breast carcinoma.

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1
ICI/University Joint Laboratory, University of Leicester, UK.

Abstract

We have identified a rearranged c-myc gene in DNA from tumour tissue from a patient with an aggressive carcinoma of the breast. Analysis of this rearranged gene isolated from a size-fractionated genomic library revealed that a deletion had occurred within exon 3. This deletion, of approximately 5 kb, interrupts the coding region of exon 3, and would result in a truncated myc protein with an altered C-terminus. Sequence analysis of the rearranged c-myc gene and the sequence downstream of c-myc which is involved in the deletion has shown precisely where the breakpoint has occurred in both sequences and reveals a short region of homology which could perhaps permit illegitimate recombination between the two sequences.

PMID:
2838785
[Indexed for MEDLINE]
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