Visible-light-mediated radical insertion/cyclization cascade reaction: synthesis of phenanthridines and isoquinolines from isocyanides

Shangbiao Feng; Tao Li; Chenglong Du; Peng Chen; Dengpeng Song; Jinlai Li; Xingang Xie; Xuegong She

doi:10.1039/c7cc01813d

Visible-light-mediated radical insertion/cyclization cascade reaction: synthesis of phenanthridines and isoquinolines from isocyanides

Chem Commun (Camb). 2017 Apr 20;53(33):4585-4588. doi: 10.1039/c7cc01813d.

Authors

Shangbiao Feng¹, Tao Li, Chenglong Du, Peng Chen, Dengpeng Song, Jinlai Li, Xingang Xie, Xuegong She

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China. shexg@lzu.edu.cn.

PMID: 28387777
DOI: 10.1039/c7cc01813d

Abstract

A visible-light promoted single electron oxidation of ether enabled by photoredox catalysis has been accomplished. This procedure initiates a novel radical insertion/cyclization cascade reaction to generate phenanthridines and isoquinolines from easily available isocyanides under mild reaction conditions.