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J Neurosurg Pediatr. 2017 Jul;20(1):51-55. doi: 10.3171/2017.2.PEDS16679. Epub 2017 Apr 7.

Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor.

Author information

1
Departments of 1 Neurosurgery.
2
University of California, Berkeley, California.
3
Radiology, and.
4
Pathology and Laboratory Medicine, and.
5
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and.
6
Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine.

Abstract

Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.

KEYWORDS:

6q22 deletion; CNS = central nervous system; FFPE = formalin-fixed, paraffin-embedded; GOPC; ROS1; RT-PCR = reverse transcriptase–polymerase chain reaction; RTK = receptor tyrosine kinase; oncology; receptor protein-tyrosine kinases

PMID:
28387643
DOI:
10.3171/2017.2.PEDS16679
[Indexed for MEDLINE]

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