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J Diabetes Res. 2017;2017:9328347. doi: 10.1155/2017/9328347. Epub 2017 Mar 12.

Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer.

Author information

1
Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.

Abstract

Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation.

PMID:
28386568
PMCID:
PMC5366201
DOI:
10.1155/2017/9328347
[Indexed for MEDLINE]
Free PMC Article

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