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Front Immunol. 2017 Mar 23;8:329. doi: 10.3389/fimmu.2017.00329. eCollection 2017.

Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications.

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Anthony Nolan Research Institute, London, UK; Cancer Institute, University College London, London, UK.
King Abdullah International Medical Research Center , Riyadh , Saudi Arabia.


Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transplantation but as we gain a better understanding of the characteristics of each immune cell that UCB contains, we will also be able to develop new cell therapies for cancer. In this review, we present what is currently known of the phenotype and functions of UCB NK cells and how these cells could be used in the future for cancer immunotherapy.


cancer; hematopoietic stem cells; immunotherapy; natural killer cells; umbilical cord blood

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