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Science. 2017 May 5;356(6337). pii: eaai7407. doi: 10.1126/science.aai7407. Epub 2017 Apr 6.

Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila.

Author information

1
Laboratoire de Physique Statistique, Ecole Normale Supérieure, CNRS, Université Pierre et Marie Curie, Université Paris Diderot, 75005 Paris, France. corson@lps.ens.fr fschweis@pasteur.fr.
2
Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France.
3
CNRS, UMR3738, 75015 Paris, France.
4
Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France. corson@lps.ens.fr fschweis@pasteur.fr.

Abstract

The emergence of spatial patterns in developing multicellular organisms relies on positional cues and cell-cell communication. Drosophila sensory organs have informed a paradigm in which these operate in two distinct steps: Prepattern factors drive localized proneural activity, then Notch-mediated lateral inhibition singles out neural precursors. Here we show that self-organization through Notch signaling also establishes the proneural stripes that resolve into rows of sensory bristles on the fly thorax. Patterning, initiated by a gradient of Delta ligand expression, progresses through inhibitory signaling between and within stripes. Thus, Notch signaling can support self-organized tissue patterning as a prepattern is transduced by cell-cell interactions into a refined arrangement of cellular fates.

PMID:
28386027
DOI:
10.1126/science.aai7407
[Indexed for MEDLINE]

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