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Biol Psychol. 2017 May;126:41-47. doi: 10.1016/j.biopsycho.2017.04.003. Epub 2017 Apr 3.

Abnormal self-schema in semantic memory in major depressive disorder: Evidence from event-related brain potentials.

Author information

1
Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: michael.kiang@camh.ca.
2
Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
3
Department of Cognitive Science and Department of Neurosciences, University of California (San Diego), La Jolla, CA, USA.
4
St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
5
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Abstract

An overly negative self-schema is a proposed cognitive mechanism of major depressive disorder (MDD). Self-schema - one's core conception of self, including how strongly one believes one possesses various characteristics - is part of semantic memory (SM), our knowledge about concepts and their relationships. We used the N400 event-related potential (ERP) - elicited by meaningful stimuli, and reduced by greater association of the stimulus with preceding context - to measure association strength between self-concept and positive, negative, and neutral characteristics in SM. ERPs were recorded from MDD patients (n=16) and controls (n=16) who viewed trials comprising a self-referential phrase followed by a positive, negative, or neutral adjective. Participants' task was to indicate via button-press whether or not they felt each adjective described themselves. Controls endorsed more positive adjectives than did MDD patients, but the opposite was true for negative adjectives. Patients had smaller N400s than controls specifically for negative adjectives, suggesting that MDD is associated with stronger than normal functional neural links between self-concept and negative characteristics in SM.

KEYWORDS:

Electroencephalography; Event-related potentials; Language; Major depressive disorder; Self-schema; Semantic memory

PMID:
28385626
DOI:
10.1016/j.biopsycho.2017.04.003
[Indexed for MEDLINE]

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