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Int J Cardiol. 2017 Aug 1;240:221-227. doi: 10.1016/j.ijcard.2017.03.103. Epub 2017 Mar 28.

Atrial fibrillation risk in metabolically healthy obesity: A nationwide population-based study.

Author information

1
Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
2
Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: choiek17@snu.ac.kr.
3
Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: hwanx2@catholic.ac.kr.
4
Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
5
Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
6
Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea.

Abstract

BACKGROUND:

Metabolically healthy obese (MHO) individuals are reported to have a marginal increase in cardiovascular risk; however, their atrial fibrillation (AF) risk is unclear. We aimed to assess AF risk in MHO individuals and identify whether AF development is associated with obesity or influenced by metabolic comorbidities.

METHODS:

A retrospective cohort of 389,321 individuals (age, 45.6±14.5years; male, 52.1%) was extracted from the Korean National Health Insurance sample database between 2004 and 2006 and followed-up for new-onset AF until 2013. Subjects with diabetes mellitus, hypertension, and/or dyslipidemia were classified as "metabolically unhealthy." The cohort was stratified into four groups according to obesity and metabolic healthiness: metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), MHO, and metabolically unhealthy obese (MUO).

RESULTS:

AF was newly diagnosed in 5106 (1.3%) individuals during a mean follow-up of 7.5±1.5years. The AF incidence rates for the MHNO, MUNO, MHO, and MUO groups were 0.76, 2.66, 1.10, and 2.88 per 1000 person-years, respectively. Compared with the MHNO group, the MHO group had increased AF risk (adjusted hazard ratio, 1.30; 95% CI, 1.14-1.48) on multivariate analysis. One fourth of the MHO cohort became metabolically unhealthy, contributing to increased AF risk. Obesity was an independent risk factor for AF, and increased AF risk by 20%. Metabolic unhealthiness increased AF risk by around 40%, and of its components, hypertension contributed the most.

CONCLUSIONS:

MHO individuals are at increased risk for AF development, and obesity was independently associated with elevated AF risk.

KEYWORDS:

Atrial fibrillation; Epidemiology; Metabolically healthy obesity; Obesity; Risk factors

PMID:
28385358
DOI:
10.1016/j.ijcard.2017.03.103
[Indexed for MEDLINE]

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